{"product_id":"nad-500-mg-pen","title":"NAD⁺ 500 mg pen","description":"\u003cp\u003eNicotinamide adenine dinucleotide (NAD⁺) is a vital coenzyme involved in cellular metabolism, DNA repair, and mitochondrial function. In rat models, NAD⁺ supplementation has been extensively studied, revealing its potential in mitigating various pathological conditions.One significant area of research focuses on NAD⁺’s neuroprotective effects. In a study examining chronic cerebral hypoperfusion in rats, NAD⁺ administration improved cognitive function and reduced neuroinflammation by enhancing mitochondrial function and decreasing reactive oxygen species production. This suggests NAD⁺’s potential in treating neurodegenerative diseases.\u003c\/p\u003e\n\u003cp\u003eFurthermore, NAD⁺ has been implicated in enhancing exercise endurance. A study demonstrated that treatment with NAD⁺ and honokiol improved exercise capacity in rats by restoring SIRT3 levels in skeletal muscles and enhancing mitochondrial complex I levels.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eSafety assessments of NAD⁺ precursors like nicotinamide riboside (NR) have also been conducted. A 90-day oral toxicity study in Sprague-Dawley rats found no adverse effects at doses up to 1,200 mg\/kg\/day, supporting the safe use of NR in long-term studies.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eAdditionally, NAD⁺ supplementation has been shown to protect against spinal cord ischemia-reperfusion injury in rats by reducing oxidative stress-induced neuronal apoptosis, highlighting its potential in treating spinal cord injuries.\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003cp\u003eThese findings underscore the therapeutic potential of NAD⁺ in various disease models. However, further research is necessary to fully elucidate its mechanisms and translate these benefits into clinical applications.\u003c\/p\u003e","brand":"Pharmaco.shop UAE","offers":[{"title":"Default Title","offer_id":45082707591344,"sku":null,"price":1100.0,"currency_code":"AED","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0703\/7793\/0928\/files\/rn-image_picker_lib_temp_818e674b-4b25-4a62-a47c-3e499f34792c.jpg?v=1777891208","url":"https:\/\/pharmacom.co\/products\/nad-500-mg-pen","provider":"Pharmacom ","version":"1.0","type":"link"}